Germantown is a neighborhood three miles southeast of downtown Louisville, Kentucky, USA. Germantown is also a general term for an area of Louisville from the Original Highlands to St Josephand Bradley neighborhoods that were predominantly settled by Germans. The actual neighborhood is bounded by Barrett Ave, Eastern Parkway, and the South Fork of Beargrass Creek.

The area was settled as small farms and butcher shops by Germanimmigrants in the 1870s. At this time area was nicknamed 'Frogtown' because the adjacent Beargrass Creek frequently flooded the area, causing numerous epidemics of malaria. The flooding problem was solved when Beargrass Creek was routed into a much deeper concrete canal. The area was subdivided and developed heavily during the 1890s, when the largest collection of shotgun houses in the city of Louisville was built.