St. Matthews is the 20th largest city in Kentucky,United Statesand is a prominent suburb of Louisville. It is located 8 miles east of downtown Louisville in Jefferson County. It is one of the state's major shopping areas, being home to second and fifth largest malls in Kentucky (Mall St. Matthews and Oxmoor Center), respectively, along with many smaller shopping centers along Shelbyville Road.

In 2003 St. Matthews became part of the new "Louisville Metro" government. It remains an independent city with its own mayor and emergency services. It is not counted in Louisville's population, although its citizens can vote for Louisville Mayor and Metro Council members.